Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Loss-of-function variants in CTNNA1 detected on multigene panel testing in individuals with gastric or breast cancer.

Genetics in medicine : official journal of the American College of Medical Genetics - 1 May 2020

Clark Dana Farengo, Michalski Scott T, Tondon Rashmi, Nehoray Bita, Ebrahimzadeh Jessica, Hughes Sarah Kate, Soper Emily R, Domchek Susan M, Rustgi Anil K, Pineda-Alvarez Daniel, Anderson Michael J, Katona Bryson W

Abstract excerpt

PURPOSE: CTNNA1 is a potential diffuse gastric cancer risk gene, however CTNNA1 testing on multigene panel testing (MGPT) remains unstudied. METHODS: De-identified data from 151,425 individuals who underwent CTNNA1 testing at a commercial laboratory between October 2015 and July 2019 were reviewed. Tissue α-E-catenin immunohistochemistry was performed on CTNNA1 c.1351C>T (p.Arg451*) carriers. RESULTS: Fifty-two...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to alpha Catenin
Share to Breast Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Penetrance

Share to Stomach Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 32051609
DOI: 10.1038/s41436-020-0753-1
PMCID: PMC7200596

Genes

CTNNA1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Loss-of-function variants in CTNNA1 detected on multigene panel testing in individuals with gastric or breast cancer.PMID 32051609Read ↗

Hereditary diffuse gastric cancer spectrum associated with germline CTNNA1 loss of function revealed by clinical and molecular data from 351 carrier families and over 37 000 non-carrier controls.Semantic proximity Read ↗

First estimates of diffuse gastric cancer risks for carriers of CTNNA1 germline pathogenic variants.Semantic proximity Read ↗

A Japanese family of hereditary diffuse gastric cancer with a germline pathogenic variant of CTNN1A detected via comprehensive genome profiling.Semantic proximity Read ↗

Unexpected CDH1 Mutations Identified on Multigene Panels Pose Clinical Management ChallengesSemantic proximity Read ↗

Exome sequencing reveals three novel candidate predisposition genes for diffuse gastric cancer.Semantic proximity Read ↗

CTNND1 is involved in germline predisposition to early-onset gastric cancer by affecting cell-to-cell interactions.Semantic proximity Read ↗

Cancer predisposition and germline CTNNA1 variants.Semantic proximity Read ↗

Monoallelic NTHL1 p.(Gln90*) and cancer risk: evidence from a large Turkish cohort.Semantic proximity Read ↗

An α-E-catenin (CTNNA1) mutation in hereditary diffuse gastric cancer.Semantic proximity Read ↗

CDH1 on Multigene Panel Testing: Look Before You Leap.Semantic proximity Read ↗

Simplified and more sensitive criteria for identifying individuals with pathogenic CDH1 variants.Semantic proximity Read ↗

Multigene Germline Panel Testing in Gastric Cancer Patients in a Portuguese Population.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.