Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Gram-negative bacteria and their lipopolysaccharides in Alzheimer’s disease: pathologic roles and therapeutic implications

1 Dec 2021

Abstract excerpt

Alzheimer's disease (AD) is the most serious age-related neurodegenerative disease and causes destructive and irreversible cognitive decline. Failures in the development of therapeutics targeting amyloid-β (Aβ) and tau, principal proteins inducing pathology in AD, suggest a paradigm shift towards the development of new therapeutic targets. The gram-negative bacteria and lipopolysaccharides (LPS) are attractive...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Neuroinflammation and Neurodegeneration Mechanisms
Share to Tryptophan and brain disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34876226
DOI: 10.1186/s40035-021-00273-y

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Gram-negative bacteria and their lipopolysaccharides in Alzheimer’s disease: pathologic roles and therapeutic implicationsPMID 34876226Read ↗

Gram-negative bacterial molecules associate with Alzheimer disease pathologySemantic proximity Read ↗

The menace within: bacterial amyloids as a trigger for autoimmune and neurodegenerative diseasesSemantic proximity Read ↗

Implications of Microorganisms in Alzheimer’s DiseaseSemantic proximity Read ↗

Alzheimer’s disease and infectious agents: a comprehensive review of pathogenic mechanisms and microRNA rolesSemantic proximity Read ↗

The role of microbiome-host interactions in the development of Alzheimer´s diseaseSemantic proximity Read ↗

The Periodontal Pathogen Fusobacterium nucleatum Exacerbates Alzheimer’s Pathogenesis via Specific PathwaysSemantic proximity Read ↗

Biofilm Biology to Brain Health: Harnessing Microbial Wisdom to Uncover Amyloid Dissociating Bifunctional Nano Chaperones for Alzheimer’s TherapeuticsSemantic proximity Read ↗

A Bacterial Component to Alzheimer’s-Type Dementia Seen via a Systems Biology Approach that Links Iron Dysregulation and Inflammagen Shedding to DiseaseSemantic proximity Read ↗

Porphyromonas gingivalis Outer Membrane Vesicles as the Major Driver of and Explanation for Neuropathogenesis, the Cholinergic Hypothesis, Iron Dyshomeostasis, and Salivary Lactoferrin in Alzheimer’s DiseaseSemantic proximity Read ↗

MAD—microbial (origin of) Alzheimer’s disease hypothesis: from infection and the antimicrobial response to disruption of key copper-based systemsSemantic proximity Read ↗

The gut microbiota affects amyloid deposition in Alzheimer’s disease models by suppressing immune-mediated Aβ clearanceSemantic proximity Read ↗

Bacterial DNA promotes Tau aggregationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.