Article
Plasma Circulating Tumor DNA and Clonal Hematopoiesis in Metastatic Renal Cell Carcinoma.
Clinical genitourinary cancer - 1 Aug 2020
Bacon Jack V W, Annala Matti, Soleimani Maryam, Lavoie Jean-Michel, So Alan, Gleave Martin E, Fazli Ladan, Wang Gang, Chi Kim N, Kollmannsberger Christian K, Wyatt Alexander W, Nappi Lucia
Abstract excerpt
BACKGROUND: There is a lack of molecularly-informed biomarkers for patients with metastatic renal cell carcinoma (RCC). Plasma cell-free DNA (cfDNA) sequencing is a minimally-invasive alternative to tissue for profiling the genome in other cancers but relevance in metastatic RCC remains unclear. MATERIALS AND METHODS: Whole blood was collected from 55 patients with metastatic RCC. Plasma cfDNA and leukocyte DNA...
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