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Article

Circulating tumour DNA sequence analysis as an alternative to multiple myeloma bone marrow aspirates.

Nature communications - 11 May 2017

Kis Olena, Kaedbey Rayan, Chow Signy, Danesh Arnavaz, Dowar Mark, Li Tiantian, Li Zhihua, Liu Jessica, Mansour Mark, Masih-Khan Esther, Zhang Tong, Bratman Scott V, Oza Amit M, Kamel-Reid Suzanne, Trudel Suzanne, Pugh Trevor J

Abstract excerpt

The requirement for bone-marrow aspirates for genomic profiling of multiple myeloma poses an obstacle to enrolment and retention of patients in clinical trials. We evaluated whether circulating cell-free DNA (cfDNA) analysis is comparable to molecular profiling of myeloma using bone-marrow tumour cells. We report here a hybrid-capture-based Liquid Biopsy Sequencing (LB-Seq) method used to sequence all...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28492226
DOI: 10.1038/ncomms15086
PMCID: PMC5437268

Genes

BRAF
EGFR
KRAS
NRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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