Complementary Role of Circulating Tumor DNA Assessment and Tissue Genomic Profiling in Metastatic Renal Cell Carcinoma.

doi:10.1158/1078-0432.CCR-21-0572

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Complementary Role of Circulating Tumor DNA Assessment and Tissue Genomic Profiling in Metastatic Renal Cell Carcinoma.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Sept 2021

Zengin Zeynep B, Weipert Caroline, Salgia Nicholas J, Dizman Nazli, Hsu Joann, Meza Luis, Chehrazi-Raffle Alexander, Muddasani Ramya, Salgia Sabrina, Malhotra Jasnoor, Chawla Neal, Philip Errol J, Kiedrowski Lesli, Maughan Benjamin L, Rathi Nityam, Goel Divyam, Choueiri Toni K, Agarwal Neeraj, Pal Sumanta K

Abstract excerpt

PURPOSE: The role of circulating cell-free tumor DNA (ctDNA) as an adjunct to tissue genomic profiling is poorly defined in metastatic renal cell carcinoma (mRCC). In this study, we aim to validate previous findings related to genomic alteration (GA) frequency in ctDNA and determine the concordance between ctDNA and tissue-based profiling in patients with mRCC. EXPERIMENTAL DESIGN: Results of 839 patients with...

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PMID: 34130999
DOI: 10.1158/1078-0432.CCR-21-0572

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