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Article

Concurrent tissue and circulating tumor DNA analysis in renal cell carcinoma: insights from a multimodal database.

The oncologist - 10 Apr 2026

Jani Chinmay T, Tran Elizabeth, Jaeger Ellen, Dong Jianjie, Husni Nabil, Stoppler Melissa C, Hockenberry Adam J, Mercer Jacob, Pal Sumanta, Agarwal Neeraj, Choueiri Toni K, Rose Brent, Bagrodia Aditya, McKay Rana R

Abstract excerpt

INTRODUCTION: Circulating tumor DNA (ctDNA) sequencing complements tissue-based next-generation sequencing (NGS), offering noninvasive and serial testing. We explore the mutational landscape of renal cell carcinoma (RCC) using matched tissue and ctDNA data to assess complementarity and clinical significance of molecular alterations. METHODS: From the Tempus multimodal database, we retrospectively analyzed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41926756
DOI: 10.1093/oncolo/oyag123
PMCID: PMC13127420

Genes

PBRM1
VHL
BAP1
SETD2
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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