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Article

The effect of liver enzymes on body composition: A Mendelian randomization study.

PloS one - 1 Jan 2020

Liu Junxi, Au Yeung Shiu Lun, Kwok Man Ki, Leung June Yue Yan, Hui Lai Ling, Leung Gabriel Matthew, Schooling C Mary

Abstract excerpt

BACKGROUND: Higher alanine transaminase (ALT), indicating poor liver function, is positively associated with diabetes but inversely associated with body mass index (BMI) in Mendelian randomization (MR) studies, suggesting liver function affects muscle mass. To clarify, we assessed the associations of liver enzymes with muscle and fat mass observationally with two-sample MR as a validation. METHODS: In the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32045441
DOI: 10.1371/journal.pone.0228737
PMCID: PMC7012438

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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