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Article

Retromer controls epithelial cell polarity by trafficking the apical determinant Crumbs.

Current biology : CB - 12 Jul 2011

Pocha Shirin Meher, Wassmer Thomas, Niehage Christian, Hoflack Bernard, Knust Elisabeth

Abstract excerpt

The evolutionarily conserved apical determinant Crumbs (Crb) is essential for maintaining apicobasal polarity and integrity of many epithelial tissues [1]. Crb levels are crucial for cell polarity and homeostasis, yet strikingly little is known about its trafficking or the mechanism of its apical localization. Using a newly established, liposome-based system described here, we determined Crb to be an interaction...

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Identifiers

PMID: 21700461
DOI: 10.1016/j.cub.2011.05.007

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