Article
Microarray and morphological analysis of early postnatal CRB2 mutant retinas on a pure C57BL/6J genetic background.
PloS one - 1 Jan 2013
Alves Celso Henrique, Bossers Koen, Vos Rogier M, Essing Anke H W, Swagemakers Sigrid, van der Spek Peter J, Verhaagen Joost, Wijnholds Jan
Abstract excerpt
In humans, the Crumbs homologue-1 (CRB1) gene is mutated in progressive types of autosomal recessive retinitis pigmentosa and Leber congenital amaurosis. The severity of the phenotype due to human CRB1 or mouse Crb1 mutations is dependent on the genetic background. Mice on C57BL/6J background with Crb1 mutations show late onset of retinal spotting phenotype or no phenotype. Recently, we showed that conditional...
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