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Article

A Germline CHEK2 Mutation in a Family with Papillary Thyroid Cancer.

Thyroid : official journal of the American Thyroid Association - 1 Jun 2020

Zhao Yanyang, Yu Tian, Chen Lan, Xie Donghui, Wang Feiliang, Fu Liping, Cheng Chaoze, Li Yao, Zhu Xiaoquan, Miao Gang

Abstract excerpt

Approximately 5% of all cases of papillary thyroid cancer (PTC) are inherited. However, the susceptibility gene(s) for nonsyndromic familial PTC (FPTC) remain unclear. We performed whole genome sequencing of peripheral blood DNA samples from two affected family members with PTC. CHEK2 transcript expression and the protein levels of CHK2 and p53 were evaluated in the thyroid tissues from two affected members of...

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Identifiers

PMID: 32041497
DOI: 10.1089/thy.2019.0774

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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