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Article

Association of combined genetic variations in SOD3, GPX3, PON1, and GSTT1 with hypertension and severity of coronary artery disease.

Heart and vessels - 1 Jul 2020

Decharatchakul Nisa, Settasatian Chatri, Settasatian Nongnuch, Komanasin Nantarat, Kukongviriyapan Upa, Intharapetch Pongsak, Senthong Vichai, Sawanyawisuth Kittisak

Abstract excerpt

Oxidative stress plays a critical role in the pathophysiology of hypertension (HT) and the progression of atherosclerotic coronary artery disease (CAD). Genetic variations in superoxide dismutase (SOD), glutathione peroxidase 3 (GPX3), paraoxonase 1 (PON1) and glutathione S-transferase theta 1 (GSTT1) may modulate their gene functions, affecting protein functions. These changes could have an impact on the...

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Source

Identifiers

PMID: 32034489
DOI: 10.1007/s00380-020-01564-6

Genes

CAD
GPX3
GSTT1
PON1
SOD3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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