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Article

Pluripotency of mouse spermatogonial stem cells maintained by IGF‐1‐dependent pathway

26 Feb 2009

Abstract excerpt

Recent studies indicate that neonatal spermatogonial stem cells (SSCs) possess pluripotency. However, the mechanisms that regulate the pluripotent differentiation capacity of SSCs remain unclear. Here, we describe a new method to clonally derive pluripotent SSCs from neonatal mouse testis. By coculturing with testicular stromal cells, SSCs can be maintained and expanded in serum-free conditions. Unlike endogenous...

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PMID: 19246485
DOI: 10.1096/fj.08-121939

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