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Article

Presence of PTPN2 SNP rs1893217 Enhances the Anti-inflammatory Effect of Spermidine.

Inflammatory bowel diseases - 18 Jun 2020

Niechcial Anna, Butter Matthias, Manz Salomon, Obialo Nicole, Bäbler Katharina, van der Lely Lisa, Lang Silvia, Gottier Claudia, McCole Declan F, Scharl Michael, Spalinger Marianne R

Abstract excerpt

BACKGROUND: The single nucleotide polymorphism (SNP) rs1893217 within the gene locus encoding PTPN2 represents a risk factor for inflammatory bowel disease (IBD). Our previous work demonstrated reduced PTPN2 activity and subsequently increased inflammatory signaling upon presence of SNP rs1893217. The naturally occurring polyamine spermidine reduces pro-inflammatory signaling via induction of PTPN2 activity;...

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Identifiers

PMID: 32031616
DOI: 10.1093/ibd/izaa013
PMCID: PMC7931847

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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