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Functional Architecture of Deleterious Genetic Variants in the Genome of a Wrangel Island Mammoth.

Genome biology and evolution - 1 Mar 2020

Fry Erin, Kim Sun K, Chigurapti Sravanthi, Mika Katelyn M, Ratan Aakrosh, Dammermann Alexander, Mitchell Brian J, Miller Webb, Lynch Vincent J

Abstract excerpt

Woolly mammoths were among the most abundant cold-adapted species during the Pleistocene. Their once-large populations went extinct in two waves, an end-Pleistocene extinction of continental populations followed by the mid-Holocene extinction of relict populations on St. Paul Island ∼5,600 years ago and Wrangel Island ∼4,000 years ago. Wrangel Island mammoths experienced an episode of rapid demographic decline...

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PMID: 32031213
DOI: 10.1093/gbe/evz279
PMCID: PMC7094797

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