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Article

UsnRNP trafficking is regulated by stress granules and compromised by mutant ALS proteins.

Neurobiology of disease - 1 May 2020

Rossi Simona, Rompietti Valentina, Antonucci Ylenia, Giovannini Daniela, Scopa Chiara, Scaricamazza Silvia, Scardigli Raffaella, Cestra Gianluca, Serafino Annalucia, Carrì Maria Teresa, D'Ambrosi Nadia, Cozzolino Mauro

Abstract excerpt

Activation of the integrated stress response (ISR), alterations in nucleo-cytoplasmic (N/C) transport and changes in alternative splicing regulation are all common traits of the pathogenesis of Amyotrophic Lateral Sclerosis (ALS). However, whether these processes act independently from each other, or are part of a coordinated mechanism of gene expression regulation that is affected in pathogenic conditions, is...

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PMID: 32027933
DOI: 10.1016/j.nbd.2020.104792

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