HLA associations with infliximab-induced liver injury.

doi:10.1038/s41397-020-0159-0

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Article

HLA associations with infliximab-induced liver injury.

The pharmacogenomics journal - 1 Oct 2020

Bruno Christopher D, Fremd Brandon, Church Rachel J, Daly Ann K, Aithal Guruprasad P, Björnsson Einar S, Larrey Dominique, Watkins Paul B, Chow Christina R

Abstract excerpt

Biomarkers that are able to identify patients at risk of drug-induced liver injury (DILI) after treatment with infliximab could be important in increasing the safety of infliximab use. We performed a genetic analysis to identify possible human leukocyte antigen (HLA) associations with DILI in European Caucasian users of infliximab in a retrospective study of 16 infliximab-DILI patients and 60 matched controls. In...

Topics

Adolescent
Adult
Anti-Inflammatory Agents
Chemical and Drug Induced Liver Injury
Child
Female
Genome-Wide Association Study
HLA Antigens
HLA-B39 Antigen
HLA-B8 Antigen
HLA-DQ beta-Chains

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

HLA-DRB1 Chains

Humans

Infliximab

Male

Middle Aged

Pharmacogenetics

Pharmacogenomic Variants

Source

Open in PubMed

Identifiers

PMID: 32024945
DOI: 10.1038/s41397-020-0159-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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