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Article

Distinct immune phenotypes in infants developing asthma during childhood.

Science translational medicine - 5 Feb 2020

Thysen Anna Hammerich, Waage Johannes, Larsen Jeppe Madura, Rasmussen Morten Arendt, Stokholm Jakob, Chawes Bo, Fink Nadia Rahman, Pedersen Tine Marie, Wolsk Helene, Thorsteinsdottir Sunna, Litman Thomas, Renz Harald, Bønnelykke Klaus, Bisgaard Hans, Brix Susanne

Abstract excerpt

Early exposure to environmental triggers may elicit trajectories to chronic inflammatory disease through deregulated immune responses. To address relations between early immune competence and development of childhood asthma, we performed functional immune profiling of 186 parameters in blood of 541 18-month-old infants and examined links between their response phenotype and development of transient or persistent...

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PMID: 32024797
DOI: 10.1126/scitranslmed.aaw0258

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