Estrogen receptor alpha gene variant, PvuII (rs2234693), as a potential pharmacogenetic biomarker for aneurysmal subarachnoid hemorrhage in postmenopausal women.

doi:10.1038/s41397-020-0155-4

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Article

Estrogen receptor alpha gene variant, PvuII (rs2234693), as a potential pharmacogenetic biomarker for aneurysmal subarachnoid hemorrhage in postmenopausal women.

The pharmacogenomics journal - 1 Oct 2020

Ramesh Shruthi Shimoga, Christopher Rita, Devi Bhagavatula Indira, Bhat Dhananjaya Ishwar, Shukla Dhaval

Abstract excerpt

Aneurysmal subarachnoid hemorrhage (aSAH) occurs more often in postmenopausal women than in men. Estrogen plays an important role in vascular homeostasis. Our aim was to elucidate whether a drop in circulating estradiol in conjunction with variants of estrogen receptor genes have a role in female gender susceptibility to aSAH. A total of 709 subjects were enrolled (349 aSAH patients, 360 controls) and genotyped...

Topics

Adult
Aged
Case-Control Studies
Estradiol
Estrogen Receptor alpha
Female
Genetic Association Studies
Genotype
Humans
Male
Middle Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pharmacogenomic Variants

Phenotype

Postmenopause

Risk Assessment

Risk Factors

Sex Factors

Subarachnoid Hemorrhage

Source

Open in PubMed

Identifiers

PMID: 32015458
DOI: 10.1038/s41397-020-0155-4

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