Article
Association study of estrogen receptor alpha gene polymorphisms with spontaneous abortion: is this a possible reason for unexplained spontaneous abortion?
BioMed research international - 1 Jan 2013
Anousha Negin, Hossein-Nezhad Arash, Biramijamal Firouzeh, Rahmani Ali, Maghbooli Zhila, Aghababaei Elahe, Nemati Shahram
Abstract excerpt
Estrogen plays a crucial role in fetal and placental development through estrogen receptors. Association of estrogen receptor alpha gene (ESR1) polymorphisms with spontaneous abortion has been shown in some studies. Our main goal was to study the potential association of spontaneous abortion with the ESR1 gene variations (PvuII and XbaI) in fetal tissue. Totally, 161 samples were recruited including 80 samples of...
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