Article
Bezafibrate Improves Mitochondrial Fission and Function in DNM1L-Deficient Patient Cells.
Cells - 27 Jan 2020
Douiev Liza, Sheffer Ruth, Horvath Gabriella, Saada Ann
Abstract excerpt
Mitochondria are involved in many cellular processes and their main role is cellular energy production. They constantly undergo fission and fusion, and these counteracting processes are under strict balance. The cytosolic dynamin-related protein 1, Drp1, or dynamin-1-like protein (DNM1L) mediates mitochondrial and peroxisomal division. Defects in the DNM1L gene result in a complex neurodevelopmental disorder with...
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