Article
Sex specific effect of ATPase inhibitory factor 1 on body weight: studies in high fat diet induced obese mice and genetic association studies in humans.
Metabolism: clinical and experimental - 1 Apr 2020
Kwak So-Young, Chung InHyeok, Kang Joon, Perakakis Nikolaos, Yoo Eun Hye, Lee Juhee, Jung Hun Taek, Mun Bo-Ram, Choi Won-Seok, Kim Oh Yoen, Kim Seolsong, Kim Eun-Kyoung, Oh Hannah, Mantzoros Christos S, Chung Ji Hyung, Kim Hyeon Soo, Shin Min-Jeong
Abstract excerpt
BACKGROUND: Based on the metabolic effect of exogenous ATPase inhibitory factor 1 (IF1) on glucose metabolism, we tested whether IF1 treatment is effective in ameliorating weight gain and whether its effects are sex specific. METHODS: HFD-fed C57BL/6 mice were treated with IF1 (5 mg/kg body weight, injected intraperitoneally). The underlying mechanisms of effect of IF1 on body weight were investigated in vitro...
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