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Article

PARP1 V762A polymorphism affects the prognosis of myelodysplastic syndromes.

European journal of haematology - 1 Jun 2020

Gotoh Nanami, Minato Yusuke, Saitoh Takayuki, Takahashi Noriyuki, Kasamatsu Tetsuhiro, Souma Kana, Oda Tsukasa, Hoshino Takumi, Sakura Toru, Ishizaki Takuma, Shimizu Hiroaki, Takizawa Makiko, Yokohama Akihiko, Tsukamoto Norifumi, Handa Hiroshi, Murakami Hirokazu

Abstract excerpt

OBJECTIVE: Myelodysplastic syndromes (MDS), caused by various genetic mutations in hematopoietic stem cells, are associated with highly variable outcomes. Poly (ADP-ribose) polymerase-1 (PARP1) plays an important role in DNA damage repair and contributes to the progression of several types of cancer. Here, we investigated the impact of PARP1 V762A polymorphism on the susceptibility to and prognosis of MDS....

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Identifiers

PMID: 32003046
DOI: 10.1111/ejh.13393

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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