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Targeting p53 and histone methyltransferases restores exhausted CD8+ T cells in HCV infection

30 Jan 2020

Abstract excerpt

Hepatitis C virus infection (HCV) represents a unique model to characterize, from early to late stages of infection, the T cell differentiation process leading to exhaustion of human CD8+ T cells. Here we show that in early HCV infection, exhaustion-committed virus-specific CD8+ T cells display a marked upregulation of transcription associated with impaired glycolytic and mitochondrial functions, that are linked...

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PMID: 32001678
DOI: 10.1038/s41467-019-14137-7

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