Article
Genetic lineage tracing reveals poor angiogenic potential of cardiac endothelial cells.
Cardiovascular research - 1 Jan 2021
Kocijan Tea, Rehman Michael, Colliva Andrea, Groppa Elena, Leban Matteo, Vodret Simone, Volf Nina, Zucca Gabriele, Cappelletto Ambra, Piperno Giulia Maria, Zentilin Lorena, Giacca Mauro, Benvenuti Federica, Zhou Bin, Adams Ralf H, Zacchigna Serena
Abstract excerpt
AIMS: Cardiac ischaemia does not elicit an efficient angiogenic response. Indeed, lack of surgical revascularization upon myocardial infarction results in cardiomyocyte death, scarring, and loss of contractile function. Clinical trials aimed at inducing therapeutic revascularization through the delivery of pro-angiogenic molecules after cardiac ischaemia have invariably failed, suggesting that endothelial cells...
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