Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Article

Evaluation of the interaction between genetic variants of GAD1 and miRNA in bipolar disorders.

Journal of affective disorders - 1 Dec 2017

Chung Yu-Chu Ella, Chen Shao-Chien, Chuang Li-Chung, Shih Wei-Liang, Chiu Yi-Hang, Lu Mong-Liang, Chen Hsi-Chung, Kuo Po-Hsiu

Abstract excerpt

BACKGROUND: Glutamic acid dehydrogenase 1 (GAD1) serves as the rate-limiting enzyme for synthesizing GABA, and is reported to be associated with several psychiatric disorders. The present study examined the effects of GAD1 genetic variants on bipolar disorder (BD) and its subtypes. Moreover, we investigated functional interactions between genetic variants and miRNAs via algorithm prediction and experimental...

Topics

Adult
Asian People
Bipolar Disorder
Case-Control Studies
Female
Genetic Markers
Genetic Predisposition to Disease
Genetic Variation
Genotype
Glutamate Decarboxylase
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

MicroRNAs

Polymorphism, Single Nucleotide

Risk Factors

Taiwan

Source

Identifiers

PMID: 28710909
DOI: 10.1016/j.jad.2017.07.024

Genes

GAD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evaluation of the interaction between genetic variants of GAD1 and miRNA in bipolar disorders.PMID 28710909Read ↗

Systematic study of association of four GABAergic genes: glutamic acid decarboxylase 1 gene, glutamic acid decarboxylase 2 gene, GABA(B) receptor 1 gene and GABA(A) receptor subunit beta2 gene, with schizophrenia using a universal DNA microarray.Semantic proximity Read ↗

GAD1 alternative transcripts and DNA methylation in human prefrontal cortex and hippocampus in brain development, schizophrenia.Semantic proximity Read ↗

Variant GADL1 and response to lithium therapy in bipolar I disorder.Semantic proximity Read ↗

Glutamatergic and HPA-axis pathway genes in bipolar disorder comorbid with alcohol- and substance use disorders.Semantic proximity Read ↗

Analysis of the Influence of microRNAs in Lithium Response in Bipolar DisorderSemantic proximity Read ↗

Comprehensive analysis of polymorphisms throughout GAD1 gene: a family-based association study in schizophrenia.Semantic proximity Read ↗

Genetic and functional analyses implicate microRNA 499A in bipolar disorder development.Semantic proximity Read ↗

Mutational screening and association study of glutamate decarboxylase 1 as a candidate susceptibility gene for bipolar affective disorder and schizophrenia.Semantic proximity Read ↗

No association between the glutamate decarboxylase 67 gene (GAD1) and schizophrenia in the Japanese population.Semantic proximity Read ↗

MIR218 polygenic risk score is associated with cognitive function and neurochemical metabolites among patients with depressed bipolar disorders.Semantic proximity Read ↗

Gender differences in associations of glutamate decarboxylase 1 gene (GAD1) variants with panic disorder.Semantic proximity Read ↗

Association of genetic variation in CACNA1C with bipolar disorder in Han Chinese.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.