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Article

Norrin Protects Retinal Ganglion Cells from Excitotoxic Damage via the Induction of Leukemia Inhibitory Factor.

Cells - 23 Jan 2020

Kassumeh Stefan, Leopold Stephanie, Fuchshofer Rudolf, Thomas Carina N, Priglinger Siegfried G, Tamm Ernst R, Ohlmann Andreas

Abstract excerpt

PURPOSE: To investigate whether and how leukemia inhibitory factor (Lif) is involved in mediating the neuroprotective effects of Norrin on retinal ganglion cells (RGC) following excitotoxic damage. Norrin is a secreted protein that protects RGC from N-methyl-d-aspartate (NMDA)-mediated excitotoxic damage, which is accompanied by increased expression of protective factors such as Lif, Edn2 and Fgf2. METHODS:...

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Identifiers

PMID: 31979254
DOI: 10.3390/cells9020277
PMCID: PMC7072268

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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