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Article

Acquisition of RGC phenotype in human Müller glia with stem cell characteristics is accompanied by upregulation of functional nicotinic acetylcholine receptors.

Molecular vision - 1 Jan 2013

Becker Silke, Singhal Shweta, Jones Megan F, Eastlake Karen, Cottrill Phillippa B, Jayaram Hari, Limb G Astrid

Abstract excerpt

PURPOSE: Human Müller glia with stem cell characteristics (hMGSCs) can be induced to express genes and proteins of retinal ganglion cells (RGCs) upon in vitro inhibition of Notch-1 activity. However, it is not known whether expression of these markers is accompanied by acquisition of RGC function. This study investigated whether hMGSCs that express RGC markers also display neural functionality, as measured by...

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Source

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Identifiers

PMID: 24049438
PMCID: PMC3774575

Genes

HES1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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