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Article

Methylation of the ataxia telangiectasia mutated gene (ATM) promoter as a radiotherapy outcome biomarker in patients with hepatocellular carcinoma.

Medicine - 1 Jan 2020

Yan Xinjian, Wu Tianyu, Tang Mei, Chen Dongliang, Huang Meiyuan, Zhou Sichun, Zhang Huihui, Yang Xiaoping, Li Gaofeng

Abstract excerpt

The goal of this study was to evaluate the contribution of ataxia telangiectasia mutated (ATM) gene promoter methylation to hepatocellular carcinoma (HCC) and the predictive value of radiotherapy outcome. ATM promoter methylation status was detected using methylation-specific PCR in 118 HCC, 50 adjacent liver, and 20 normal liver samples. PCR products were verified by bisulfite sequencing PCR. ATM expression was...

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Share to Ataxia Telangiectasia Mutated Proteins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinoma, Hepatocellular

Share to DNA Methylation

Share to Gene Expression Regulation, Neoplastic

Share to Liver Neoplasms

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Share to Real-Time Polymerase Chain Reaction

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Identifiers

PMID: 31977876
DOI: 10.1097/MD.0000000000018823
PMCID: PMC7004781

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