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Article

Essential gene identification and drug target prioritization in Aspergillus fumigatus.

PLoS pathogens - 1 Mar 2007

Hu Wenqi, Sillaots Susan, Lemieux Sebastien, Davison John, Kauffman Sarah, Breton Anouk, Linteau Annie, Xin Chunlin, Bowman Joel, Becker Jeff, Jiang Bo, Roemer Terry

Abstract excerpt

Aspergillus fumigatus is the most prevalent airborne filamentous fungal pathogen in humans, causing severe and often fatal invasive infections in immunocompromised patients. Currently available antifungal drugs to treat invasive aspergillosis have limited modes of action, and few are safe and effective. To identify and prioritize antifungal drug targets, we have developed a conditional promoter replacement (CPR)...

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Identifiers

PMID: 17352532
DOI: 10.1371/journal.ppat.0030024
PMCID: PMC1817658

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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