Article
Peripheral axonal ensheathment is regulated by RalA GTPase and the exocyst complex.
Development (Cambridge, England) - 4 Feb 2020
Silva-Rodrigues Joana F, Patrício-Rodrigues Cátia F, de Sousa-Xavier Vicente, Augusto Pedro M, Fernandes Ana C, Farinho Ana R, Martins João P, Teodoro Rita O
Abstract excerpt
Axon ensheathment is fundamental for fast impulse conduction and the normal physiological functioning of the nervous system. Defects in axonal insulation lead to debilitating conditions, but, despite its importance, the molecular players responsible are poorly defined. Here, we identify RalA GTPase as a key player in axon ensheathment in Drosophila larval peripheral nerves. We demonstrate through genetic analysis...
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