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Article

Association of the IL16 Asn1147Lys polymorphism with intravenous immunoglobulin resistance in Kawasaki disease.

Journal of human genetics - 1 Apr 2020

Kim Hea-Ji, Kim Jae-Jung, Yun Sin Weon, Yu Jeong Jin, Yoon Kyung Lim, Lee Kyung-Yil, Kil Hong-Ryang, Kim Gi Beom, Han Myung-Ki, Song Min Seob, Lee Hyoung Doo, Ha Kee Soo, Hong Young Mi, Jang Gi Young, Lee Jong-Keuk

Abstract excerpt

Kawasaki disease (KD) is an acute, self-limited vasculitis, mainly affecting children younger than 5 years old, with accompanying fever and signs of mucocutaneous inflammation. Intravenous immunoglobulin (IVIG) is the standard treatment for KD; however, ~15% of patients are resistant to IVIG treatment. To identify protein coding genetic variants influencing IVIG resistance, we re-analyzed our previous genome-wide...

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PMID: 31965063
DOI: 10.1038/s10038-020-0721-2

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