Article
Biallelic Alteration and Dysregulation of the Hippo Pathway in Mucinous Tubular and Spindle Cell Carcinoma of the Kidney.
Cancer discovery - 1 Nov 2016
Mehra Rohit, Vats Pankaj, Cieslik Marcin, Cao Xuhong, Su Fengyun, Shukla Sudhanshu, Udager Aaron M, Wang Rui, Pan Jincheng, Kasaian Katayoon, Lonigro Robert, Siddiqui Javed, Premkumar Kumpati, Palapattu Ganesh, Weizer Alon, Hafez Khaled S, Wolf J Stuart, Sangoi Ankur R, Trpkov Kiril, Osunkoya Adeboye O, Zhou Ming, Giannico Giovanna, McKenney Jesse K, Dhanasekaran Saravana M, Chinnaiyan Arul M
Abstract excerpt
Mucinous tubular and spindle cell carcinoma (MTSCC) is a relatively rare subtype of renal cell carcinoma (RCC) with distinctive morphologic and cytogenetic features. Here, we carry out whole-exome and transcriptome sequencing of a multi-institutional cohort of MTSCC (n = 22). We demonstrate the presence of either biallelic loss of Hippo pathway tumor suppressor genes (TSG) and/or evidence of alteration of Hippo...
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