Article
Synucleinopathies: Where we are and where we need to go.
Journal of neurochemistry - 1 May 2020
Brás Inês Caldeira, Dominguez-Meijide Antonio, Gerhardt Ellen, Koss David, Lázaro Diana F, Santos Patrícia I, Vasili Eftychia, Xylaki Mary, Outeiro Tiago Fleming
Abstract excerpt
Synucleinopathies are a group of disorders characterized by the accumulation of inclusions rich in the a-synuclein (aSyn) protein. This group of disorders includes Parkinson's disease, dementia with Lewy bodies (DLB), multiple systems atrophy, and pure autonomic failure (PAF). In addition, genetic alterations (point mutations and multiplications) in the gene encoding for aSyn (SNCA) are associated with familial...
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