Article
Identification of genetic polymorphisms modulating nausea and vomiting in two series of opioid-treated cancer patients.
Scientific reports - 17 Jan 2020
Colombo Francesca, Pintarelli Giulia, Galvan Antonella, Noci Sara, Corli Oscar, Skorpen Frank, Klepstad Pål, Kaasa Stein, Pigni Alessandra, Brunelli Cinzia, Roberto Anna, Piazza Rocco, Pirola Alessandra, Gambacorti-Passerini Carlo, Caraceni Augusto Tommaso
Abstract excerpt
Nausea and vomiting are often associated with opioid analgesia in cancer patients; however, only a subset of patients develop such side effects. Here, we tested the hypothesis that the occurrence of nausea and vomiting is modulated by the genetic background of the patients. Whole exome sequencing of DNA pools from patients with either low (n = 937) or high (n = 557) nausea and vomiting intensity, recruited in the...
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