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Maximizing the ovarian reserve in mice by evading LINE-1 genotoxicity

16 Jan 2020

Abstract excerpt

Female reproductive success critically depends on the size and quality of a finite ovarian reserve. Paradoxically, mammals eliminate up to 80% of the initial oocyte pool through the enigmatic process of fetal oocyte attrition (FOA). Here, we interrogate the striking correlation of FOA with retrotransposon LINE-1 (L1) expression in mice to understand how L1 activity influences FOA and its biological relevance. We...

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PMID: 31949138
DOI: 10.1038/s41467-019-14055-8

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