Article
Improvement of epidermal covering on AEC patients with severe skin erosions by PRIMA-1MET/APR-246.
Cell death & disease - 16 Jan 2020
Aberdam Edith, Roux Lauriane N, Secrétan Philippe-Henri, Boralevi Franck, Schlatter Joël, Morice-Picard Fanny, Sol Stefano, Bodemer Christine, Missero Caterina, Cisternino Salvatore, Aberdam Daniel, Hadj-Rabia Smail
Abstract excerpt
P63 is a major transcription factor regulating skin development and homeostasis. It controls many genes involved in cell proliferation, adhesion, and early differentiation. P63 is mutated in several rare syndromes called p63-related ectodermal dysplasia syndromes (ED). The main forms are EEC and AEC syndromes due to p63 missense mutations on the DBD and SAM domains, respectively. ED patients display many...
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