Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Development of skin-humanized mouse models of pachyonychia congenita.

The Journal of investigative dermatology - 1 May 2011

García Marta, Larcher Fernando, Hickerson Robyn P, Baselga Eulalia, Leachman Sancy A, Kaspar Roger L, Del Rio Marcela

Abstract excerpt

Molecular characterization and assessment of therapeutic outcomes for inherited cutaneous disorders requires faithful preclinical models. In this study we report the establishment of two different skin-humanized pachyonychia congenita (PC) model systems, based on permanent engraftment of bioengineered skin equivalents generated from patient skin cells onto immunodeficient mice. Using keratinocytes and fibroblasts...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blister
Share to Disease Models, Animal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fibroblasts

Share to Keratin-6

Share to Keratinocytes

Share to Mice, Nude

Source

Identifiers

PMID: 21150925
DOI: 10.1038/jid.2010.353

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Development of skin-humanized mouse models of pachyonychia congenita.PMID 21150925Read ↗

Mouse models in preclinical studies for pachyonychia congenita.Semantic proximity Read ↗

Overcoming functional redundancy to elicit pachyonychia congenita-like nail lesions in transgenic mice.Semantic proximity Read ↗

Keratin 16-null mice develop palmoplantar keratoderma, a hallmark feature of pachyonychia congenita and related disorders.Semantic proximity Read ↗

The phenotypic and molecular genetic features of pachyonychia congenita.Semantic proximity Read ↗

Pachyonychia Congenita: A Research Agenda Leading to New Therapeutic Approaches.Semantic proximity Read ↗

Transgrediens pachyonychia congenita (PC): case series of a nonclassical PC presentation.Semantic proximity Read ↗

Keratin K6c mutations cause focal palmoplantar keratoderma.Semantic proximity Read ↗

Proteomic profiling of Pachyonychia congenita plantar callus.Semantic proximity Read ↗

Pachyonychia Congenita: A Spectrum of KRT6a Mutations in Australian Patients.Semantic proximity Read ↗

Revisiting pachyonychia congenita: a case-cohort study of 815 patients.Semantic proximity Read ↗

Clinical and pathological features of pachyonychia congenita.Semantic proximity Read ↗

Modeling normal and pathological processes through skin tissue engineeringSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.