Emergence and Adaptation of a Novel Highly Pathogenic H7N9 Influenza Virus in Birds and Humans from a 2013 Human-Infecting Low-Pathogenic Ancestor.

doi:10.1128/JVI.00921-17

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Article

Emergence and Adaptation of a Novel Highly Pathogenic H7N9 Influenza Virus in Birds and Humans from a 2013 Human-Infecting Low-Pathogenic Ancestor.

Journal of virology - 15 Jan 2018

Qi Wenbao, Jia Weixin, Liu Di, Li Jing, Bi Yuhai, Xie Shumin, Li Bo, Hu Tao, Du Yingying, Xing Li, Zhang Jiahao, Zhang Fuchun, Wei Xiaoman, Eden John-Sebastian, Li Huanan, Tian Huaiyu, Li Wei, Su Guanming, Lao Guangjie, Xu Chenggang, Xu Bing, Liu Wenjun, Zhang Guihong, Ren Tao, Holmes Edward C, Cui Jie, Shi Weifeng, Gao George F, Liao Ming

Abstract excerpt

Since its emergence in 2013, the H7N9 low-pathogenic avian influenza virus (LPAIV) has been circulating in domestic poultry in China, causing five waves of human infections. A novel H7N9 highly pathogenic avian influenza virus (HPAIV) variant possessing multiple basic amino acids at the cleavage site of the hemagglutinin (HA) protein was first reported in two cases of human infection in January 2017. More...

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PMID: 29070694
DOI: 10.1128/JVI.00921-17
PMCID: PMC5752946

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