Article
Phenotype-genotype network construction and characterization: a case study of cardiovascular diseases and associated non-coding RNAs.
Database : the journal of biological databases and curation - 1 Jan 2020
Wu Rongrong, Lin Yuxin, Liu Xingyun, Zhan Chaoying, He Hongxin, Shi Manhong, Jiang Zhi, Shen Bairong
Abstract excerpt
The phenotype-genotype relationship is a key for personalized and precision medicine for complex diseases. To unravel the complexity of the clinical phenotype-genotype network, we used cardiovascular diseases (CVDs) and associated non-coding RNAs (ncRNAs) (i.e. miRNAs, long ncRNAs, etc.) as the case for the study of CVDs at a systems or network level. We first integrated a database of CVDs and ncRNAs (CVDncR,...
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