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Article

Impact of EGFR-TKI Treatment on the Tumor Immune Microenvironment in EGFR Mutation-Positive Non-Small Cell Lung Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Apr 2020

Isomoto Kohsuke, Haratani Koji, Hayashi Hidetoshi, Shimizu Shigeki, Tomida Shuta, Niwa Takashi, Yokoyama Toshihide, Fukuda Yasushi, Chiba Yasutaka, Kato Ryoji, Tanizaki Junko, Tanaka Kaoru, Takeda Masayuki, Ogura Takashi, Ishida Tadashi, Ito Akihiko, Nakagawa Kazuhiko

Abstract excerpt

PURPOSE: The impact of EGFR tyrosine kinase inhibitors (TKI) on the tumor immune microenvironment (TME) in non-small cell lung cancer (NSCLC) is unclear. EXPERIMENTAL DESIGN: We retrospectively identified 138 patients with EGFR-mutated NSCLC who underwent rebiopsy after progression during EGFR-TKI treatment. PD-L1 and CD73 expression in tumor cells and tumor-infiltrating lymphocyte (TIL) density at baseline and...

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Identifiers

PMID: 31937613
DOI: 10.1158/1078-0432.CCR-19-2027

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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