Article
Genetic variation in alcohol dehydrogenase is associated with neurocognition in men with HIV and history of alcohol use disorder: preliminary findings.
Journal of neurovirology - 1 Apr 2020
Saloner Rowan, Paolillo Emily W, Kohli Maulika, Murray Sarah S, Moore David J, Grant Igor, Cherner Mariana
Abstract excerpt
The co-occurrence of HIV and alcohol use disorder (AUD) amplifies risk for neural injury and neurocognitive deficits. However, the substantial neurocognitive heterogeneity across HIV+/AUD+ individuals suggests inter-individual differences in vulnerability to the neurotoxicity of comorbid HIV/AUD. Genetic variation in alcohol dehydrogenase (ADH), which metabolizes ethanol, may contribute to inter-individual...
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