Article
Distinct Subpopulations of Intravalvular Methicillin-Resistant Staphylococcus aureus with Variable Susceptibility to Daptomycin in Tricuspid Valve Endocarditis.
Antimicrobial agents and chemotherapy - 21 Feb 2020
Miller Christopher R, Dey Somrita, Smolenski Paula D, Kulkarni Pushkar S, Monk Jonathan M, Szubin Richard, Sakoulas George, Berti Andrew D
Abstract excerpt
We present a case of endocarditis wherein organisms cultured from different valve leaflets yielded different daptomycin susceptibilities from each other and from organisms obtained from peripheral blood culture. Genomic analyses showed mutations in mprF, purR, and agrA Pharmacokinetic simulations showed consistent activity of daptomycin plus beta-lactam against all subpopulations. This represents an opportunity...
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