Article
Evolution and single-nucleotide polymorphisms in methicillin-resistant Staphylococcus aureus strains with reduced susceptibility to vancomycin and daptomycin, based on determination of the complete genome.
Antimicrobial agents and chemotherapy - 1 Jan 2015
Yamaguchi Tetsuo, Suzuki Shingo, Okamura Sakiko, Miura Yuri, Tsukimori Ayaka, Nakamura Itaru, Ito Norihiko, Masuya Anri, Shiina Takashi, Matsumoto Tetsuya
Abstract excerpt
We obtained a series of methicillin-resistant Staphylococcus aureus isolates, including both daptomycin-susceptible strain TD1 and daptomycin-resistant strain TD4, from a patient. We determined the complete genome sequences of TD1 and TD4 using next-generation sequencing, and only four single-nucleotide polymorphisms (SNPs) were identified, one each in capB (E58K), rpoB (H481Y), lytN (I16V), and mprF (V351E). We...
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