miR-30-5p-mediated ferroptosis of trophoblasts is implicated in the pathogenesis of preeclampsia

Abstract excerpt

Oxidative stress is a major cause of adverse outcomes in preeclampsia (PE). Ferroptosis, i.e. programmed cell death from iron-dependent lipid peroxidation, likely mediates PE pathogenesis. We evaluated specific markers for ferroptosis in normal and PE placental tissues, using in vitro (trophoblasts) and in vivo (rat) models. Increase in malondialdehyde content and total Fe 2+ along with reduced the glutathione...

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