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p53-mediated suppression of the SLC7 A11/GPX4 signaling pathway promotes trophoblast ferroptosis in preeclampsia

28 May 2025

Abstract excerpt

BACKGROUND: Ferroptosis is an iron-dependent form of non-apoptotic cell death that occurs through increased plasma membrane phospholipid peroxidation in the context of impaired plasma membrane phospholipid peroxide repair systems. It has been reported that p53 can inhibit the expression of cysteine/glutamate reverse transporter solute carrier family 7, member 11 (SLC7A11), a key component of system Xc-, thus...

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PMID: 40437575
DOI: 10.1186/s12915-025-02240-9

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