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Article

Contribution of synergism between PHF8 and HER2 signalling to breast cancer development and drug resistance

1 Jan 2020

Abstract excerpt

Background HER2 plays a critical role in tumourigenesis and is associated with poor prognosis of patients with HER2-positive breast cancers. Although anti-HER2 drugs are beneficial for treating breast cancer, de novo , or acquired resistance often develops. Epigenetic factors are increasingly targeted for therapy; however, such mechanisms that interact with HER2 signalling are poorly understood. Methods RNA...

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PMID: 31923801
DOI: 10.1016/j.ebiom.2019.102612

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