Article
Genetic variant rs3750625 in the 3'UTR of ADRA2A affects the sleep quality of patients in the ICU by promoting miR‑34a binding to ADRA2A.
International journal of molecular medicine - 1 Mar 2020
Huang Qingping, Chen Ganhai, Huang Yanfang, Li Jinting, Ding Yanjing, Zhang Shuqing, Chi Xiuwen, Xie Qiong, Ning Qinrong, Xu Liuqin, Zhang Jianrong
Abstract excerpt
Poor sleep is very common in patients in the ICU and hence, sleep quality is considered an important aspect of intensive care; however, the underlying mechanisms of poor sleep in patients in the ICU remain unknown. In this study, we aimed to explore the role of rs3750625, which is located in the 3'UTR of adrenoceptor alpha 2A (ADRA2A), in sleep quality. For this purpose, luciferase assay was conducted to...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.