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Article

Genetic variant rs3750625 in the 3'UTR of ADRA2A affects stress-dependent acute pain severity after trauma and alters a microRNA-34a regulatory site.

Pain - 1 Feb 2017

Linnstaedt Sarah D, Walker Margaret G, Riker Kyle D, Nyland Jennifer E, Hu JunMei, Rossi Catherine, Swor Robert A, Jones Jeffrey S, Diatchenko Luda, Bortsov Andrey V, Peak David A, McLean Samuel A

Abstract excerpt

α2A adrenergic receptor (α2A-AR) activation has been shown in animal models to play an important role in regulating the balance of acute pain inhibition vs facilitation after both physical and psychological stress. To our knowledge, the influence of genetic variants in the gene encoding α2A-AR, ADRA2A, on acute pain outcomes in humans experiencing traumatic stress has not been assessed. In this study, we tested...

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Identifiers

PMID: 27805929
DOI: 10.1097/j.pain.0000000000000742
PMCID: PMC5239739

Genes

ADRA2A
AR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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