Article
A Porphyromonas gingivalis mutant defective in a putative glycosyltransferase exhibits defective biosynthesis of the polysaccharide portions of lipopolysaccharide, decreased gingipain activities, strong autoaggregation, and increased biofilm formation.
Infection and immunity - 1 Sept 2010
Yamaguchi Mikiyo, Sato Keiko, Yukitake Hideharu, Noiri Yuichiro, Ebisu Shigeyuki, Nakayama Koji
Abstract excerpt
The Gram-negative anaerobic bacterium Porphyromonas gingivalis is a major pathogen in periodontal disease, one of the biofilm-caused infectious diseases. The bacterium possesses potential virulence factors, including fimbriae, proteinases, hemagglutinin, lipopolysaccharide (LPS), and outer membrane vesicles, and some of these factors are associated with biofilm formation; however, the precise mechanism of biofilm...
Topics
- Adhesins, Bacterial
- Biofilms
- Cysteine Endopeptidases
- DNA Transposable Elements
- Gingipain Cysteine Endopeptidases
- Glycosyltransferases
- Lipopolysaccharides
- Microscopy, Electron, Scanning
- Mutation
- Porphyromonas gingivalis