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Article

Rapid non-uniform adaptation to conformation-specific KRAS(G12C) inhibition.

Nature - 1 Jan 2020

Xue Jenny Y, Zhao Yulei, Aronowitz Jordan, Mai Trang T, Vides Alberto, Qeriqi Besnik, Kim Dongsung, Li Chuanchuan, de Stanchina Elisa, Mazutis Linas, Risso Davide, Lito Piro

Abstract excerpt

KRAS GTPases are activated in one-third of cancers, and KRAS(G12C) is one of the most common activating alterations in lung adenocarcinoma1,2. KRAS(G12C) inhibitors3,4 are in phase-I clinical trials and early data show partial responses in nearly half of patients with lung cancer. How cancer cells bypass inhibition to prevent maximal response to therapy is not understood. Because KRAS(G12C) cycles between an...

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Identifiers

PMID: 31915379
DOI: 10.1038/s41586-019-1884-x
PMCID: PMC7308074

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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